Systems biology of JAK-STAT signalling in human malignancies

Julio Vera; Katja Rateitschak; Falko Lange; Christina Kossow; Olaf Wolkenhauer; Robert Jaster

doi:10.1016/j.pbiomolbio.2011.06.013

Systems biology of JAK-STAT signalling in human malignancies

Julio Vera, Katja Rateitschak, Falko Lange, Christina Kossow, Olaf Wolkenhauer^*, Robert Jaster

^*Corresponding author for this work

University of Rostock

Research output: Contribution to journal › Review article / Perspectives › peer-review

49 Scopus citations

Abstract

Originally implicated in the regulation of survival, proliferation and differentiation of haematopoietic cells, the JAK-STAT pathway has also been linked to developmental processes, growth control and maintenance of homeostasis in a variety of other cells and tissues. Although it remains a complex system, its relative simplicity and the availability of molecular data makes it particularly attractive for modelling approaches. In this review, we will focus on JAK-STAT signalling in the context of cancer and present efforts to investigate signalling dynamics with the help of mathematical models. We describe the modelling workflow that realises a systems biology approach and give an example for interferon-γ signalling in pancreatic stellate cells.

Original language	English
Pages (from-to)	426-434
Number of pages	9
Journal	Progress in Biophysics and Molecular Biology
Volume	106
Issue number	2
DOIs	https://doi.org/10.1016/j.pbiomolbio.2011.06.013
State	Published - Aug 2011
Externally published	Yes

Keywords

Cell signalling
Interferon-γ
JAK-STAT
Mathematical modelling
Pancreatic stellate cell
STAT1

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10.1016/j.pbiomolbio.2011.06.013

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AU - Kossow, Christina

AU - Wolkenhauer, Olaf

AU - Jaster, Robert

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AB - Originally implicated in the regulation of survival, proliferation and differentiation of haematopoietic cells, the JAK-STAT pathway has also been linked to developmental processes, growth control and maintenance of homeostasis in a variety of other cells and tissues. Although it remains a complex system, its relative simplicity and the availability of molecular data makes it particularly attractive for modelling approaches. In this review, we will focus on JAK-STAT signalling in the context of cancer and present efforts to investigate signalling dynamics with the help of mathematical models. We describe the modelling workflow that realises a systems biology approach and give an example for interferon-γ signalling in pancreatic stellate cells.

KW - Cell signalling

KW - Interferon-γ

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KW - Mathematical modelling

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KW - STAT1

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ER -

Systems biology of JAK-STAT signalling in human malignancies

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Keywords

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