Synthesis of 13C-Labeled Patulin [4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one] to Be Used as Internal Standard in a Stable Isotope Dilution Assay

M. Rychlik; P. Schieberle

doi:10.1021/jf980506p

Synthesis of ¹³C-Labeled Patulin [4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one] to Be Used as Internal Standard in a Stable Isotope Dilution Assay

M. Rychlik, P. Schieberle^*

^*Corresponding author for this work

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A synthetic route was established for the preparation of [¹³C₂]-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one (patulin) to be used in a stable isotope dilution assay. Mass spectral analyses were performed using electron impact ionization (EI), negative electrospray ionization (ESI), collision-induced dissociation (CID), and atmospheric pressure ionization. Fragmentation routes in the EI mode and in CID were concluded and compared with each other.

Original language	English
Pages (from-to)	5163-5169
Number of pages	7
Journal	Journal of Agricultural and Food Chemistry
Volume	46
Issue number	12
DOIs	https://doi.org/10.1021/jf980506p
State	Published - Dec 1998
Externally published	Yes

Keywords

Atmospheric pressure chemical ionization (APCI)
Electrospray ionization (ESI)
Patulin
Stable isotope dilution assay

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10.1021/jf980506p

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title = "Synthesis of 13C-Labeled Patulin [4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one] to Be Used as Internal Standard in a Stable Isotope Dilution Assay",

abstract = "A synthetic route was established for the preparation of [13C2]-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one (patulin) to be used in a stable isotope dilution assay. Mass spectral analyses were performed using electron impact ionization (EI), negative electrospray ionization (ESI), collision-induced dissociation (CID), and atmospheric pressure ionization. Fragmentation routes in the EI mode and in CID were concluded and compared with each other.",

keywords = "Atmospheric pressure chemical ionization (APCI), Electrospray ionization (ESI), Patulin, Stable isotope dilution assay",

author = "M. Rychlik and P. Schieberle",

year = "1998",

month = dec,

doi = "10.1021/jf980506p",

language = "English",

volume = "46",

pages = "5163--5169",

journal = "Journal of Agricultural and Food Chemistry",

issn = "0021-8561",

publisher = "American Chemical Society",

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T1 - Synthesis of 13C-Labeled Patulin [4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one] to Be Used as Internal Standard in a Stable Isotope Dilution Assay

AU - Rychlik, M.

AU - Schieberle, P.

PY - 1998/12

Y1 - 1998/12

N2 - A synthetic route was established for the preparation of [13C2]-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one (patulin) to be used in a stable isotope dilution assay. Mass spectral analyses were performed using electron impact ionization (EI), negative electrospray ionization (ESI), collision-induced dissociation (CID), and atmospheric pressure ionization. Fragmentation routes in the EI mode and in CID were concluded and compared with each other.

AB - A synthetic route was established for the preparation of [13C2]-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one (patulin) to be used in a stable isotope dilution assay. Mass spectral analyses were performed using electron impact ionization (EI), negative electrospray ionization (ESI), collision-induced dissociation (CID), and atmospheric pressure ionization. Fragmentation routes in the EI mode and in CID were concluded and compared with each other.

KW - Atmospheric pressure chemical ionization (APCI)

KW - Electrospray ionization (ESI)

KW - Patulin

KW - Stable isotope dilution assay

UR - https://www.scopus.com/pages/publications/0001283837

U2 - 10.1021/jf980506p

DO - 10.1021/jf980506p

M3 - Article

AN - SCOPUS:0001283837

SN - 0021-8561

VL - 46

SP - 5163

EP - 5169

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 12

ER -

Synthesis of ¹³C-Labeled Patulin [4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one] to Be Used as Internal Standard in a Stable Isotope Dilution Assay

Abstract

Keywords

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