Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis

Nicole Kretschy; Ann Katrin Holik; Veronika Somoza; Klaus Peter Stengele; Mark M. Somoza

doi:10.1002/anie.201502125

Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis

Nicole Kretschy, Ann Katrin Holik, Veronika Somoza, Klaus Peter Stengele, Mark M. Somoza^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays.

Original language	English
Pages (from-to)	8555-8559
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	29
DOIs	https://doi.org/10.1002/anie.201502125
State	Published - 13 Jul 2015
Externally published	Yes

Keywords

microarrays
photochemistry
photolysis
protecting groups

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10.1002/anie.201502125

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abstract = "Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays.",

keywords = "microarrays, photochemistry, photolysis, protecting groups",

author = "Nicole Kretschy and Holik, \{Ann Katrin\} and Veronika Somoza and Stengele, \{Klaus Peter\} and Somoza, \{Mark M.\}",

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year = "2015",

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doi = "10.1002/anie.201502125",

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AU - Kretschy, Nicole

AU - Holik, Ann Katrin

AU - Somoza, Veronika

AU - Stengele, Klaus Peter

AU - Somoza, Mark M.

PY - 2015/7/13

Y1 - 2015/7/13

N2 - Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays.

AB - Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays.

KW - microarrays

KW - photochemistry

KW - photolysis

KW - protecting groups

UR - https://www.scopus.com/pages/publications/84946072042

U2 - 10.1002/anie.201502125

DO - 10.1002/anie.201502125

M3 - Article

C2 - 26036777

AN - SCOPUS:84946072042

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JF - Angewandte Chemie - International Edition

IS - 29

ER -

Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis

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Keywords

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