(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Céline Cosseau; Olaf Wolkenhauer; Gilda Padalino; Kathrin K. Geyer; Karl F. Hoffmann; Christoph Grunau

doi:10.1016/j.pt.2016.12.002

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino, Kathrin K. Geyer, Karl F. Hoffmann, Christoph Grunau^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article / Perspectives › peer-review

30 Scopus citations

Abstract

The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	Trends in Parasitology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.pt.2016.12.002
State	Published - 1 Apr 2017
Externally published	Yes

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title = "(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach",

abstract = "The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by {\textquoteleft}inheritance system{\textquoteright}. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.",

author = "C{\'e}line Cosseau and Olaf Wolkenhauer and Gilda Padalino and Geyer, \{Kathrin K.\} and Hoffmann, \{Karl F.\} and Christoph Grunau",

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T1 - (Epi)genetic Inheritance in Schistosoma mansoni

T2 - A Systems Approach

AU - Cosseau, Céline

AU - Wolkenhauer, Olaf

AU - Padalino, Gilda

AU - Geyer, Kathrin K.

AU - Hoffmann, Karl F.

AU - Grunau, Christoph

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.

AB - The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.

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DO - 10.1016/j.pt.2016.12.002

M3 - Review article / Perspectives

C2 - 28040375

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EP - 294

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 4

ER -

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

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