TY - JOUR
T1 - Dynamics of biological systems
T2 - Role of systems biology in medical research
AU - Assmus, Heike E.
AU - Herwig, Ralf
AU - Cho, Kwang Hyun
AU - Wolkenhauer, Olaf
PY - 2006
Y1 - 2006
N2 - Cellular systems are networks of interacting components that change with time in response to external and internal events. Studying the dynamic behavior of these networks is the basis for an understanding of cellular functions and disease mechanisms. Quantitative time-series data leading to meaningful models can improve our knowledge of human physiology in health and disease, and aid the search for earlier diagnoses, better therapies and a healthier life. The advent of systems biology is about to take the leap into clinical research and medical applications. This review emphasizes the importance of a dynamic view and understanding of cell function. We discuss the potential for computer-aided mathematical modeling of biological systems in medical research with examples from some of the major therapeutic areas: cancer, cardiovascular, diabetic and neurodegenerative medicine.
AB - Cellular systems are networks of interacting components that change with time in response to external and internal events. Studying the dynamic behavior of these networks is the basis for an understanding of cellular functions and disease mechanisms. Quantitative time-series data leading to meaningful models can improve our knowledge of human physiology in health and disease, and aid the search for earlier diagnoses, better therapies and a healthier life. The advent of systems biology is about to take the leap into clinical research and medical applications. This review emphasizes the importance of a dynamic view and understanding of cell function. We discuss the potential for computer-aided mathematical modeling of biological systems in medical research with examples from some of the major therapeutic areas: cancer, cardiovascular, diabetic and neurodegenerative medicine.
KW - Computer simulation
KW - Dynamic behavior
KW - Mathematical modeling
KW - Predictive medicine
KW - Systems biology
UR - https://www.scopus.com/pages/publications/33845466621
U2 - 10.1586/14737159.6.6.891
DO - 10.1586/14737159.6.6.891
M3 - Review article / Perspectives
C2 - 17140376
AN - SCOPUS:33845466621
SN - 1473-7159
VL - 6
SP - 891
EP - 902
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
IS - 6
ER -