COVID-19 and the Chemical Senses: Supporting Players Take Center Stage

Keiland W. Cooper; David H. Brann; Michael C. Farruggia; Surabhi Bhutani; Robert Pellegrino; Tatsuya Tsukahara; Caleb Weinreb; Paule V. Joseph; Eric D. Larson; Valentina Parma; Mark W. Albers; Linda A. Barlow; Sandeep Robert Datta; Antonella Di Pizio

doi:10.1016/j.neuron.2020.06.032

COVID-19 and the Chemical Senses: Supporting Players Take Center Stage

Keiland W. Cooper (First Author), David H. Brann (Co-Author), Michael C. Farruggia (Co-Author), Surabhi Bhutani (Co-Author), Robert Pellegrino (Co-Author), Tatsuya Tsukahara (Co-Author), Caleb Weinreb (Co-Author), Paule V. Joseph (Co-Author), Eric D. Larson (Co-Author), Valentina Parma (Co-Author), Mark W. Albers (Co-Author), Linda A. Barlow^* (Co-Author), Sandeep Robert Datta^* (Co-Author), Antonella Di Pizio^* (Last Author)

^*Corresponding author for this work

Molecular Modeling

Research output: Contribution to journal › Review article / Perspectives › peer-review

250 Scopus citations

Abstract

The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.

Original language	English
Pages (from-to)	219-233
Number of pages	15
Journal	Neuron
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2020.06.032
State	Published - 22 Jul 2020

Access to Document

10.1016/j.neuron.2020.06.032

Cite this

@article{2246c5f0bd2949e5906f2c4a1be18841,

title = "COVID-19 and the Chemical Senses: Supporting Players Take Center Stage",

abstract = "The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.",

author = "Cooper, \{Keiland W.\} and Brann, \{David H.\} and Farruggia, \{Michael C.\} and Surabhi Bhutani and Robert Pellegrino and Tatsuya Tsukahara and Caleb Weinreb and Joseph, \{Paule V.\} and Larson, \{Eric D.\} and Valentina Parma and Albers, \{Mark W.\} and Barlow, \{Linda A.\} and Datta, \{Sandeep Robert\} and \{Di Pizio\}, Antonella",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jul,

day = "22",

doi = "10.1016/j.neuron.2020.06.032",

language = "English",

volume = "107",

pages = "219--233",

journal = "Neuron",

issn = "0896-6273",

number = "2",

}

TY - JOUR

T1 - COVID-19 and the Chemical Senses

T2 - Supporting Players Take Center Stage

AU - Cooper, Keiland W.

AU - Brann, David H.

AU - Farruggia, Michael C.

AU - Bhutani, Surabhi

AU - Pellegrino, Robert

AU - Tsukahara, Tatsuya

AU - Weinreb, Caleb

AU - Joseph, Paule V.

AU - Larson, Eric D.

AU - Parma, Valentina

AU - Albers, Mark W.

AU - Barlow, Linda A.

AU - Datta, Sandeep Robert

AU - Di Pizio, Antonella

PY - 2020/7/22

Y1 - 2020/7/22

N2 - The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.

AB - The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.

UR - https://www.scopus.com/pages/publications/85087504516

U2 - 10.1016/j.neuron.2020.06.032

DO - 10.1016/j.neuron.2020.06.032

M3 - Review article / Perspectives

C2 - 32640192

AN - SCOPUS:85087504516

SN - 0896-6273

VL - 107

SP - 219

EP - 233

JO - Neuron

JF - Neuron

IS - 2

ER -

COVID-19 and the Chemical Senses: Supporting Players Take Center Stage

Abstract

Access to Document

Other files and links

Fingerprint

Cite this