Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

Ute Boettler; Nadine Volz; Gudrun Pahlke; Nicole Teller; Christine Kotyczka; Veronika Somoza; Herbert Stiebitz; Gerhard Bytof; Ingo Lantz; Roman Lang; Thomas Hofmann; Doris Marko

doi:10.1002/mnfr.201100115

Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

Ute Boettler
, Nadine Volz
, Gudrun Pahlke
, Nicole Teller
, Christine Kotyczka
, Veronika Somoza
, Herbert Stiebitz
, Gerhard Bytof
, Ingo Lantz
, Roman Lang
, Thomas Hofmann
, Doris Marko^*

^*Corresponding author for this work

Metabolic Function & Biosignals

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.

Original language	English
Pages (from-to)	798-802
Number of pages	5
Journal	Molecular Nutrition and Food Research
Volume	55
Issue number	5
DOIs	https://doi.org/10.1002/mnfr.201100115
State	Published - May 2011

Keywords

Antioxidative
Chemoprevention
Coffee
Gene transcription
Nrf2 pathway

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10.1002/mnfr.201100115

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Boettler, U., Volz, N., Pahlke, G., Teller, N., Kotyczka, C., Somoza, V., Stiebitz, H., Bytof, G., Lantz, I., Lang, R., Hofmann, T., & Marko, D. (2011). Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo. Molecular Nutrition and Food Research, 55(5), 798-802. https://doi.org/10.1002/mnfr.201100115

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title = "Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo",

abstract = "Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.",

keywords = "Antioxidative, Chemoprevention, Coffee, Gene transcription, Nrf2 pathway",

author = "Ute Boettler and Nadine Volz and Gudrun Pahlke and Nicole Teller and Christine Kotyczka and Veronika Somoza and Herbert Stiebitz and Gerhard Bytof and Ingo Lantz and Roman Lang and Thomas Hofmann and Doris Marko",

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Boettler, U, Volz, N, Pahlke, G, Teller, N, Kotyczka, C, Somoza, V, Stiebitz, H, Bytof, G, Lantz, I, Lang, R, Hofmann, T & Marko, D 2011, 'Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo', Molecular Nutrition and Food Research, vol. 55, no. 5, pp. 798-802. https://doi.org/10.1002/mnfr.201100115

TY - JOUR

T1 - Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

AU - Boettler, Ute

AU - Volz, Nadine

AU - Pahlke, Gudrun

AU - Teller, Nicole

AU - Kotyczka, Christine

AU - Somoza, Veronika

AU - Stiebitz, Herbert

AU - Bytof, Gerhard

AU - Lantz, Ingo

AU - Lang, Roman

AU - Hofmann, Thomas

AU - Marko, Doris

PY - 2011/5

Y1 - 2011/5

N2 - Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.

AB - Recently, the coffee constituents 5-O-caffeoylquinic acid (CGA) and N-methylpyridinium (NMP) were identified as inducers of the Nrf2/antioxidant-response element (ARE) detoxifying pathway under cell-culture condition. To study the impact of CGA and NMP on the Nrf2-activating properties of a complex coffee beverage, two different model coffees were generated by variation of the roasting conditions: a low-roast coffee rich in CGA and a heavy-roast low in CGA but containing high levels of NMP. Activation of the Nrf2/antioxidant-response element pathway was monitored in vitro and in vivo.

KW - Antioxidative

KW - Chemoprevention

KW - Coffee

KW - Gene transcription

KW - Nrf2 pathway

UR - https://www.scopus.com/pages/publications/79955587670

U2 - 10.1002/mnfr.201100115

DO - 10.1002/mnfr.201100115

M3 - Article

C2 - 21448860

AN - SCOPUS:79955587670

SN - 1613-4125

VL - 55

SP - 798

EP - 802

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

IS - 5

ER -

Coffees rich in chlorogenic acid or N-methylpyridinium induce chemopreventive phase II-enzymes via the Nrf2/ARE pathway in vitro and in vivo

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Keywords

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