Abstract
Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 399-415 |
| Number of pages | 17 |
| Journal | Methods in Cell Biology |
| Volume | 90 |
| Issue number | C |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
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