TY - JOUR
T1 - Chapter 17 A System Biology Approach to Understand Functional Activity of Cell Communication Systems
AU - Vera, Julio
AU - Wolkenhauer, Olaf
PY - 2008
Y1 - 2008
N2 - Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.
AB - Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.
UR - https://www.scopus.com/pages/publications/59049094552
U2 - 10.1016/S0091-679X(08)00817-0
DO - 10.1016/S0091-679X(08)00817-0
M3 - Review article / Perspectives
C2 - 19195559
AN - SCOPUS:59049094552
SN - 0091-679X
VL - 90
SP - 399
EP - 415
JO - Methods in Cell Biology
JF - Methods in Cell Biology
IS - C
ER -