Celiac Disease

P. Koehler; H. Wieser; K. A. Scherf

doi:10.1016/B978-0-12-394437-5.00083-8

Celiac Disease

P. Koehler^*
, H. Wieser
, K. A. Scherf

^*Corresponding author for this work

Food Biopolymer Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Celiac disease, with a prevalence of about 1% in many countries, is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten (storage proteins of wheat, rye, barley, and oats) in genetically susceptible individuals. Small-intestinal villous atrophy is the characteristic feature, and symptoms include diarrhea or steatorrhea and extraintestinal manifestations. A strict, lifelong gluten-free diet is the current essential therapy. The complex pathomechanism consists of incomplete gluten digestion, para- and transcellular passage of gluten peptides through the epithelium, and adaptive and innate immune responses in the lamina propria.

Original language	English
Title of host publication	Nutrition and Food Grains
Publisher	Elsevier
Pages	83-90
Number of pages	8
Volume	2-4
ISBN (Electronic)	9780123947864
ISBN (Print)	9780123944375
DOIs	https://doi.org/10.1016/B978-0-12-394437-5.00083-8
State	Published - 17 Dec 2015

Keywords

Celiac disease
Cereals
Diagnosis
Epidemiology
Genetics
Gluten
Gluten-free diet
Immune response
Small intestine
Symptoms
Therapy
Toxicity

Access to Document

10.1016/B978-0-12-394437-5.00083-8

Cite this

@inbook{7dbae69dc2384040a105017c5b848255,

title = "Celiac Disease",

abstract = "Celiac disease, with a prevalence of about 1\% in many countries, is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten (storage proteins of wheat, rye, barley, and oats) in genetically susceptible individuals. Small-intestinal villous atrophy is the characteristic feature, and symptoms include diarrhea or steatorrhea and extraintestinal manifestations. A strict, lifelong gluten-free diet is the current essential therapy. The complex pathomechanism consists of incomplete gluten digestion, para- and transcellular passage of gluten peptides through the epithelium, and adaptive and innate immune responses in the lamina propria.",

keywords = "Celiac disease, Cereals, Diagnosis, Epidemiology, Genetics, Gluten, Gluten-free diet, Immune response, Small intestine, Symptoms, Therapy, Toxicity",

author = "P. Koehler and H. Wieser and Scherf, \{K. A.\}",

year = "2015",

month = dec,

day = "17",

doi = "10.1016/B978-0-12-394437-5.00083-8",

language = "English",

isbn = "9780123944375",

volume = "2-4",

pages = "83--90",

booktitle = "Nutrition and Food Grains",

publisher = "Elsevier",

}

TY - CHAP

T1 - Celiac Disease

AU - Koehler, P.

AU - Wieser, H.

AU - Scherf, K. A.

PY - 2015/12/17

Y1 - 2015/12/17

N2 - Celiac disease, with a prevalence of about 1% in many countries, is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten (storage proteins of wheat, rye, barley, and oats) in genetically susceptible individuals. Small-intestinal villous atrophy is the characteristic feature, and symptoms include diarrhea or steatorrhea and extraintestinal manifestations. A strict, lifelong gluten-free diet is the current essential therapy. The complex pathomechanism consists of incomplete gluten digestion, para- and transcellular passage of gluten peptides through the epithelium, and adaptive and innate immune responses in the lamina propria.

AB - Celiac disease, with a prevalence of about 1% in many countries, is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten (storage proteins of wheat, rye, barley, and oats) in genetically susceptible individuals. Small-intestinal villous atrophy is the characteristic feature, and symptoms include diarrhea or steatorrhea and extraintestinal manifestations. A strict, lifelong gluten-free diet is the current essential therapy. The complex pathomechanism consists of incomplete gluten digestion, para- and transcellular passage of gluten peptides through the epithelium, and adaptive and innate immune responses in the lamina propria.

KW - Celiac disease

KW - Cereals

KW - Diagnosis

KW - Epidemiology

KW - Genetics

KW - Gluten

KW - Gluten-free diet

KW - Immune response

KW - Small intestine

KW - Symptoms

KW - Therapy

KW - Toxicity

UR - https://www.scopus.com/pages/publications/85019160672

U2 - 10.1016/B978-0-12-394437-5.00083-8

DO - 10.1016/B978-0-12-394437-5.00083-8

M3 - Chapter

AN - SCOPUS:85019160672

SN - 9780123944375

VL - 2-4

SP - 83

EP - 90

BT - Nutrition and Food Grains

PB - Elsevier

ER -

Celiac Disease

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this