Bifurcation analysis of a model accounting for the 14-3-3σ signalling compartmentalisation

S. Nikolov; J. Vera; O. Wolkenhauer

doi:10.4018/978-1-4666-3604-0.ch046

Bifurcation analysis of a model accounting for the 14-3-3σ signalling compartmentalisation

S. Nikolov^*
, J. Vera
, O. Wolkenhauer

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

Bifurcation theory studies the qualitative changes in the phase portrait when we vary the parameters of the system. In this book chapter we adapt and extend a mathematical model accounting for the subcellular localisation of 14-3-3σ, a protein involved in cell cycle arrest and the regulation of apoptosis. The model is analysed with analytical tools coming from Lyapunov-Andronov theory, and our analytical calculations predict that soft (reversible) loss of stability takes place.

Original language	English
Title of host publication	Bioinformatics
Subtitle of host publication	Concepts, Methodologies, Tools, and Applications
Publisher	IGI Global
Pages	851-859
Number of pages	9
Volume	2
ISBN (Electronic)	9781466636057
ISBN (Print)	1466636041, 9781466636040
DOIs	https://doi.org/10.4018/978-1-4666-3604-0.ch046
State	Published - 31 Mar 2013
Externally published	Yes

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M3 - Chapter

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Bifurcation analysis of a model accounting for the 14-3-3σ signalling compartmentalisation

Abstract

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