Abstract
The ultimate goal of systems medicine is to understand the underlying mechanism of disease development, diagnostic biomarkers, potential drug targets, and prognosis biomarkers. Generating the context-based/tissue-specific genome-scale metabolic models fosters these goals. In the present chapter, we aim to describe the foundational concepts about metabolic modeling with focus on genome-scale metabolic reconstruction, gene expression integration into metabolic models, constraint-based modeling, model formulation, and applications of metabolic modeling in systems medicine.
| Original language | English |
|---|---|
| Title of host publication | Focus on Systems Theory Research |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 131-150 |
| Number of pages | 20 |
| ISBN (Electronic) | 9781536145625 |
| ISBN (Print) | 9781536145618 |
| State | Published - 2 Jan 2019 |
| Externally published | Yes |
Keywords
- Context-specific model
- Data integration
- Genome-scale metabolic model
- Objective function
- Systems medicine