Chemoreceptors play a key role in taste and odor perception, such as evaluating the quality of food, but are also expressed in various tissues and organs beyond the oral and nasal cavities. However, their physiological function beyond classical sensory perception remains largely unexplored. During digestion and metabolization, chemosensory active compounds may undergo enzymatic modifications, altering their chemical properties and bioactive potential. For instance, a sweet-tasting protein can be enzymatically cleaved into bitter peptides during gastric digestion, which may interact with gastric bitter receptors and thereby activate anti-inflammatory signaling pathways. The aim of the research is to investigate how exogenous compounds are modified during digestion and metabolization and to elucidate which physiological functions their metabolites can exert through interaction with extra-oral and extra-nasal chemoreceptors and associated signaling pathways.