Description
Synthetic DNA is a promising medium for routine long-term data storage. Among various synthesis methods, large-scalephotolithographic DNA synthesis, which adapts Caruthers and Beaucage's phosphoramidite chemistry for in situ surface
synthesis, offers the best scalability and cost efficiency for producing large DNA libraries.
To enhance data density beyond the standard 2 bits per coupling, trimer and composite DNA letters are used as sequence
building blocks. Composite DNA letters are created by mixing 2 to 4 DNA bases in specific ratios, which effectively expands
the DNA alphabet. These unique ratios can be identified through sequencing. Additionally, the use of trimer
phosphoramidites introduces new strategies to further improve DNA-based data storage.
| Period | 6 Sep 2024 |
|---|---|
| Event title | XXV International Round Table on Nucleosides: Nucleotides and Nucleic Acids at Katsushika Campus |
| Event type | Conference |
| Conference number | 25 |
| Location | Tokyo, JapanShow on map |
| Degree of Recognition | International |