TY - GEN
T1 - From networks to systems to complex systems
T2 - 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
AU - Soebiyanto, Radina P.
AU - Sreenath, Sree N.
AU - Mesarovic, Mihajlo D.
AU - Wolkenhauer, Olaf
PY - 2005
Y1 - 2005
N2 - Networks of signaling pathways provide a robust mechanism for cells to respond to various biological stimuli. In this paper we demonstrate cell adaptation through the viewpoint of an organizing principle between two interconnected pathways- MAPK and PKC. We use a multi-layered system representation of the pathways to determine the pathway components contributing to the adaptive behavior and coordination. The adaptation can be thought of as being manifested by a change in parameters of the coordinator. In silico experiments are conducted using MAPK/PKC mathematical model in literature to investigate the role of PLA2 as a coordinator is reported here. Our results show that varying parameters of the coordinator not only activates the network of pathways where otherwise the pathway activity is very low, but also reveal the ability of the system to activate itself in the absence of the input, indicating relevance of the principle of bounded autonomy.
AB - Networks of signaling pathways provide a robust mechanism for cells to respond to various biological stimuli. In this paper we demonstrate cell adaptation through the viewpoint of an organizing principle between two interconnected pathways- MAPK and PKC. We use a multi-layered system representation of the pathways to determine the pathway components contributing to the adaptive behavior and coordination. The adaptation can be thought of as being manifested by a change in parameters of the coordinator. In silico experiments are conducted using MAPK/PKC mathematical model in literature to investigate the role of PLA2 as a coordinator is reported here. Our results show that varying parameters of the coordinator not only activates the network of pathways where otherwise the pathway activity is very low, but also reveal the ability of the system to activate itself in the absence of the input, indicating relevance of the principle of bounded autonomy.
UR - https://www.scopus.com/pages/publications/33847176215
U2 - 10.1109/CDC.2005.1582929
DO - 10.1109/CDC.2005.1582929
M3 - Conference contribution
AN - SCOPUS:33847176215
SN - 0780395689
SN - 9780780395688
T3 - Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
SP - 4851
EP - 4856
BT - Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
Y2 - 12 December 2005 through 15 December 2005
ER -